| 言語種別 | 英語 |
|---|---|
| 発行・発表の年月 | 2021/08/17 |
| 形態種別 | 【論文】研究論文（学術雑誌）＜査読あり＞ |
| 査読 | 査読あり |
| 標題 | Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors. |
| 執筆形態 | 共著 |
| 掲載誌名 | Cell Reports |
| 掲載区分 | 国外 |
| 出版社・発行元 | Elsevier |
| 巻・号・頁 | 36(7) |
| 総ページ数 | 15 |
| 担当範囲 | I was not involved in the wet experiments in this research, but was in charge of developing the software to analyze the experimental results. |
| 著者・共著者 | Chia-Jung Tsai, Takeshi Nagata, Chih-Yao Liu, Kaspar E. Vogt, Masashi Yanagisawa, Yu Hayashi |
| 概要 | Sleep is generally viewed as a period of recovery, but how the supply of cerebral blood flow (CBF) changes across sleep/wake states has remained unclear.
Here, we directly observe red blood cells (RBCs) within capillaries, where the actual substance exchange between the blood and neurons/glia occurs, by two-photon microscopy. Capillary RBC flow during REM sleep is further elevated following REM sleep deprivation, suggesting that capillary CBF reflects REM sleep pressure. At the molecular level, signaling via adenosine A2a receptors is crucial; in A2a-KO mice, capillary CBF upsurge during REM sleep is dampened, and effects of REM sleep pressure are abolished. These results provide evidence regarding the dynamics of capillary CBF across sleep/wake states and insights to the underlying mechanisms. |
| researchmap用URL | https://www.cell.com/cell-reports/pdf/S2211-1247(21)00992-X.pdf |